|
Anorexia Nervosa
|
0.060 |
Biomarker
|
disease |
BEFREE |
We sought to: a) synthesize the available evidence on potential differences between AN patients and controls with regards to adipokine measurements (namely, leptin, adiponectin, resistin, soluble leptin receptor, visfatin, vaspin and omentin), b) estimate the potential differences between constitutionally thin (CT) subjects and AN patients, and c) present the available evidence with regards to biomarker efficacy of adipokines in AN.
|
31805456 |
2020 |
|
Anxiety
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Also, we evaluated anxiety and the expression of the leptin receptor, neuropeptides POMC, CART, NPY in the hypothalamus, as well as the serotoninergic system in the amygdala and hypothalamus as possible modulators of these behaviors.
|
31790781 |
2020 |
|
Anxiety Disorders
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Also, we evaluated anxiety and the expression of the leptin receptor, neuropeptides POMC, CART, NPY in the hypothalamus, as well as the serotoninergic system in the amygdala and hypothalamus as possible modulators of these behaviors.
|
31790781 |
2020 |
|
Androgen-Insensitivity Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Herein, we conducted this study to investigate whether there are abnormal functional responses to leptin and abnormal expression of leptin receptor in AIS osteoblasts.
|
31748652 |
2019 |
|
Multiple Sclerosis, Relapsing-Remitting
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis.
|
31704454 |
2020 |
|
LEPTIN RECEPTOR DEFICIENCY
|
0.720 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, activation of the leptin receptor ob‑R is an important pathogenic mechanism of UC, and leptin receptor deficiency may provide resistance against TNBS‑induced colitis by inhibiting the NF‑κB and RhoA signaling pathways.
|
31702041 |
2019 |
|
Ulcerative Colitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The level of serum leptin and the protein expression of the leptin receptor ob‑R in the colonic mucosa were determined in patients with UC.
|
31702041 |
2019 |
|
Sleep Apnea, Obstructive
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We aimed to clarify whether LEPR Gln223Arg polymorphism was critically involved in the development of OSAHS.
|
31679272 |
2019 |
|
Obstructive sleep apnea hypopnea syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Of the seven case-control studies we enrolled, there was insignificant correlation of the LEPR Gln223Arg polymorphism with OSAHS risk.
|
31679272 |
2019 |
|
Steatohepatitis
|
0.360 |
Biomarker
|
disease |
BEFREE |
Therefore, we hypothesized that glucagon increases hepatic LEPR, which is necessary for glucagon-mediated reversal of hepatic steatosis.
|
31673703 |
2020 |
|
Fatty Liver
|
0.350 |
Biomarker
|
disease |
BEFREE |
Therefore, we hypothesized that glucagon increases hepatic LEPR, which is necessary for glucagon-mediated reversal of hepatic steatosis.
|
31673703 |
2020 |
|
Obesity, Morbid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Leptin receptor (LepR) deficiency is an autosomal-recessive endocrine disorder causing early-onset severe obesity, hyperphagia and pituitary hormone deficiencies.
|
31658438 |
2020 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our study further emphasizes the possible causal role of LEP and LEPR with CRC, and also the prospect of using LEPR as a possible therapeutic target.
|
31592340 |
2019 |
|
Degenerative polyarthritis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Activation of the leptin pathway by high expression of the long form of the leptin receptor (Ob-Rb) accelerates chondrocyte senescence in osteoarthritis.<i>Bone Joint Res</i> 2019;8:425-436.
|
31588359 |
2019 |
|
Anxiety
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The quercetin potentiated a decrease in anxiety in W rats consumed HFCD and this effect was absent in Z rats with a defect in the leptin receptor gene.
|
31585131 |
2020 |
|
Anxiety Disorders
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The quercetin potentiated a decrease in anxiety in W rats consumed HFCD and this effect was absent in Z rats with a defect in the leptin receptor gene.
|
31585131 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Leptin receptor expression was absent or minimal in half of nodular hyperplasia tumors and adrenal cortex adenomas.
|
31572471 |
2019 |
|
Adenoma
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Leptin receptor expression was absent or minimal in half of nodular hyperplasia tumors and adrenal cortex adenomas.
|
31572471 |
2019 |
|
Multiple Sclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated whether two common variants in leptin (LEP) and leptin receptor (LEPR) genes influence MS risk and leptin levels in MS patients.
|
31563075 |
2019 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Since leptin resistance is implicated in the pathogenesis of obesity, we herein report the effects of laparoscopic sleeve gastrectomy (LSG) on the serum levels of leptin and leptin receptor, in addition to its overall effect on leptin resistance.
|
31557979 |
2019 |
|
Neonatal Opiate Withdrawal Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In NOWS requiring pharmacotherapy expression of leptin receptor, an appetite suppressor, was higher in male subjects than female subjects (Δ threshold cycle 8.4 ± 2.5 vs 12.4 ± 5.1, P = .05), DRD2 expression significantly correlated with intake volume on day of life 7 (r = 0.58, P = .02), and expression of NPY2R, an appetite regulator, negatively correlated with length of stay (r = -0.24, P = .05).
|
31474426 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we propose that vitexin alleviates NAFLD by activating AMPK possibly by binding to LepR.
|
31472955 |
2019 |
|
Rhinovirus infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.
|
31462495 |
2019 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator of both the insulin and leptin receptor phosphorylation which impacts insulin sensitivity and hence is a major therapeutic target for the treatment of type 2 diabetes and obesity.
|
31451955 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator of both the insulin and leptin receptor phosphorylation which impacts insulin sensitivity and hence is a major therapeutic target for the treatment of type 2 diabetes and obesity.
|
31451955 |
2019 |